|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Human SEMA5A ORF mammalian expression plasmid, C-GFPSpark tag||HG11300-ACG|
|Human SEMA5A ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11300-ACR|
|Human SEMA5A ORF mammalian expression plasmid, C-Flag tag||HG11300-CF|
|Human SEMA5A ORF mammalian expression plasmid, C-His tag||HG11300-CH|
|Human SEMA5A ORF mammalian expression plasmid, C-Myc tag||HG11300-CM|
|Human SEMA5A ORF mammalian expression plasmid, C-HA tag||HG11300-CY|
|Human SEMA5A Gene cDNA clone plasmid||HG11300-G|
|Human SEMA5A ORF mammalian expression plasmid, N-Flag tag||HG11300-NF|
|Human SEMA5A ORF mammalian expression plasmid, N-His tag||HG11300-NH|
|Human SEMA5A ORF mammalian expression plasmid, N-Myc tag||HG11300-NM|
|Human SEMA5A ORF mammalian expression plasmid, N-HA tag||HG11300-NY|
|Human SEMA5A natural ORF mammalian expression plasmid||HG11300-UT|
|Learn more about expression Vectors|
Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 20 semaphorins, Drosophila has five, and two are known from DNA viruses. Semaphorins are found in nematodes and crustaceans but not in non-animals. They are grouped into eight classes on the basis of phylogenetic tree analyses and the presence of additional protein motifs. Semaphorins have been implicated in diverse developmental processes such as axon guidance during nervous system development and regulation of cell migration. Semaphorin-5A, also known as Semaphorin-F, Sema F, SEMA5A and SEMAF, is a single-pass type I membrane protein which belongs to the semaphorin family. Semaphorin5A / SEMA5A contains one PSI domain, one Sema domain and seven TSP type-1 domains. It may act as positive axonal guidance cues. Semaphorin5A / SEMA5A is an axon regulator molecule and plays major roles during neuronal and vascular development. It plays an essential role in embryonic development. Semaphorin5A / SEMA5A induces endothelial cell migration from pre-existing vessels. It also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions.