|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Human LDLR ORF mammalian expression plasmid, C-GFPSpark tag||HG10231-ACG|
|Human LDLR ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10231-ACR|
|Human LDLR ORF mammalian expression plasmid, C-Flag tag||HG10231-CF|
|Human LDLR ORF mammalian expression plasmid, C-His tag||HG10231-CH|
|Human LDLR ORF mammalian expression plasmid, C-Myc tag||HG10231-CM|
|Human LDLR ORF mammalian expression plasmid, C-HA tag||HG10231-CY|
|Human LDLR Gene cDNA clone plasmid||HG10231-M|
|Human LDLR natural ORF mammalian expression plasmid||HG10231-M-N|
|Human LDLR ORF mammalian expression plasmid, N-Flag tag||HG10231-NF|
|Human LDLR ORF mammalian expression plasmid, N-His tag||HG10231-NH|
|Human LDLR ORF mammalian expression plasmid, N-Myc tag||HG10231-NM|
|Human LDLR ORF mammalian expression plasmid, N-HA tag||HG10231-NY|
|Human LDLR natural ORF mammalian expression plasmid||HG10231-UT|
|Learn more about expression Vectors|
LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.