|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Human BMP-5 ORF mammalian expression plasmid, C-GFPSpark tag||HG10214-ACG|
|Human BMP-5 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10214-ACR|
|Human BMP-5 ORF mammalian expression plasmid, C-Flag tag||HG10214-CF|
|Human BMP-5 ORF mammalian expression plasmid, C-His tag||HG10214-CH|
|Human BMP-5 ORF mammalian expression plasmid, C-Myc tag||HG10214-CM|
|Human BMP-5 ORF mammalian expression plasmid, C-HA tag||HG10214-CY|
|Human BMP-5 Gene cDNA clone plasmid||HG10214-M|
|Human BMP-5 ORF mammalian expression plasmid, Flag tag||HG10214-M-F|
|Human BMP-5 ORF mammalian expression plasmid, N-Flag tag||HG10214-NF|
|Human BMP-5 ORF mammalian expression plasmid, N-His tag||HG10214-NH|
|Human BMP-5 ORF mammalian expression plasmid, N-Myc tag||HG10214-NM|
|Human BMP-5 ORF mammalian expression plasmid, N-HA tag||HG10214-NY|
|Human BMP-5 natural ORF mammalian expression plasmid||HG10214-UT|
|Learn more about expression Vectors|
Bone Morphogenetic Protein 5 (BMP-5) is a member of the structurally and functionally related bone morphogenetic proteins (BMPs) which constitute a novel subfamily of the transforming growth factor β (TGF-β) superfamily. In agreement with a possible role in the control of cell death, BMP-5 exhibited a regulated pattern of expression in the interdigital tissue. Transcripts of BMP-5 and BMP-5 protein were abundant within the cytoplasm of the fragmenting apoptotic interdigital cells in a way suggesting that delivery of BMPs into the tissue is potentiated during apoptosis. Gain-of-function experiments demonstrated that BMP-5 has the same effect as other interdigital BMPs inducing apoptosis in the undifferentiated mesoderm and growth in the prechondrogenic mesenchyme. BMP-5 is a member of the 60A subgroup of BMPs, other members of which have been shown to stimulate dendritic growth in central and peripheral neurons. The signaling pathway that mediates the dendrite-promoting activity of BMP-5 may involve binding to BMPR-IA and activation of Smad-1, and relative levels of BMP antagonists such as noggin and follistatin may modulate BMP-5 signaling. Since BMP-5 is expressed at relatively high levels not only in the developing but also the adult nervous system, these findings suggest the possibility that BMP-5 regulates dendritic morphology not only in the developing, but also the adult nervous system. BMP-5 may play important roles not only in myocardial differentiation, but also in the formation and maintenance of endocardial cushion tissue. Additionally, high expression level of BMP-5 has been detected in certain tumors of mesenchymal origin.