|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Human NEGR1 ORF mammalian expression plasmid, C-GFPSpark tag||HG11181-ACG|
|Human NEGR1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11181-ACR|
|Human NEGR1 ORF mammalian expression plasmid, C-Flag tag||HG11181-CF|
|Human NEGR1 ORF mammalian expression plasmid, C-His tag||HG11181-CH|
|Human NEGR1 ORF mammalian expression plasmid, C-Myc tag||HG11181-CM|
|Human NEGR1 ORF mammalian expression plasmid, C-HA tag||HG11181-CY|
|Human NEGR1 Gene cDNA clone plasmid||HG11181-M|
|Human NEGR1 ORF mammalian expression plasmid, N-Flag tag||HG11181-NF|
|Human NEGR1 ORF mammalian expression plasmid, N-His tag||HG11181-NH|
|Human NEGR1 ORF mammalian expression plasmid, N-Myc tag||HG11181-NM|
|Human NEGR1 ORF mammalian expression plasmid, N-HA tag||HG11181-NY|
|Human NEGR1 natural ORF mammalian expression plasmid||HG11181-UT|
|Learn more about expression Vectors|
Neuronal Growth Regulator 1, NEGR1, also known as neurotractin, or KILON, which belongs to the immunoglobulin superfamily, IgLON family. This GPI-linked cell surface glycoprotein NEGR1 is composed of three Ig-like domains and belongs to the IgLON subgroup of neural IgSF members. It is expressed in two isoforms with apparent molecular masses of 50 and 37 kD, termed L-form and S-form, respectively. NEGR1/Neurotractin participates in the regulation of neurite outgrowth in the developing brain, and is expressed on neurites of primary hippocampal neurons. Neurotractin/KILON is a trans-neural growth-promoting factor for outgrowing axons following hippocampal denervation. KILON (kindred of IgLON) and opioid-binding cell adhesion molecule belong to the IgLON subgroup of immunoglobulin superfamily together with the limbic system-associated membrane protein and neurotrimin. The alteration of modulatory function of KILON/NEGR1 for the number of dendritic synapses concomitant with changes in its localization and detergent solubility during neuronal culture development. In addition to its reported role in the brain, NEGR1 is also expressed in subcutaneous adipose tissue and acts as a central 'hub' in an obesity-related transcript network.