|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Ferret VCAM1 ORF mammalian expression plasmid, C-GFPSpark tag||FG60134-ACG|
|Ferret VCAM1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||FG60134-ACR|
|Ferret VCAM1 ORF mammalian expression plasmid, C-Flag tag||FG60134-CF|
|Ferret VCAM1 ORF mammalian expression plasmid, C-His tag||FG60134-CH|
|Ferret VCAM1 ORF mammalian expression plasmid, C-Myc tag||FG60134-CM|
|Ferret VCAM1 ORF mammalian expression plasmid, C-HA tag||FG60134-CY|
|Ferret VCAM1 Gene cDNA clone plasmid||FG60134-G|
|Ferret VCAM1 ORF mammalian expression plasmid, N-Flag tag||FG60134-NF|
|Ferret VCAM1 ORF mammalian expression plasmid, N-His tag||FG60134-NH|
|Ferret VCAM1 ORF mammalian expression plasmid, N-Myc tag||FG60134-NM|
|Ferret VCAM1 ORF mammalian expression plasmid, N-HA tag||FG60134-NY|
|Ferret VCAM1 natural ORF mammalian expression plasmid||FG60134-UT|
|Learn more about expression Vectors|
Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.