|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
|Human IL11 ORF mammalian expression plasmid, C-GFPSpark tag||HG12225-ACG|
|Human IL11 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG12225-ACR|
|Human IL11 ORF mammalian expression plasmid, C-Flag tag||HG12225-CF|
|Human IL11 ORF mammalian expression plasmid, C-His tag||HG12225-CH|
|Human IL11 ORF mammalian expression plasmid, C-Myc tag||HG12225-CM|
|Human IL11 ORF mammalian expression plasmid, C-HA tag||HG12225-CY|
|Human IL11 Gene cDNA clone plasmid||HG12225-G|
|Human IL11 ORF mammalian expression plasmid, N-Flag tag||HG12225-NF|
|Human IL11 ORF mammalian expression plasmid, N-His tag||HG12225-NH|
|Human IL11 ORF mammalian expression plasmid, N-Myc tag||HG12225-NM|
|Human IL11 ORF mammalian expression plasmid, N-HA tag||HG12225-NY|
|Human IL11 natural ORF mammalian expression plasmid||HG12225-UT|
|Learn more about expression Vectors|
IL11 is a multifunctional cytokine first isolated in 1990 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; such functions include placentation and to some extent of decidualization.