|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rhesus CSF1 ORF mammalian expression plasmid, C-GFPSpark tag||CG90029-ACG|
|Rhesus CSF1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||CG90029-ACR|
|Rhesus CSF1 ORF mammalian expression plasmid, C-Flag tag||CG90029-CF|
|Rhesus CSF1 ORF mammalian expression plasmid, C-His tag||CG90029-CH|
|Rhesus CSF1 ORF mammalian expression plasmid, C-Myc tag||CG90029-CM|
|Rhesus CSF1 ORF mammalian expression plasmid, C-HA tag||CG90029-CY|
|Rhesus CSF1 Gene cDNA clone plasmid||CG90029-G|
|Rhesus CSF1 ORF mammalian expression plasmid, N-Flag tag||CG90029-NF|
|Rhesus CSF1 ORF mammalian expression plasmid, N-His tag||CG90029-NH|
|Rhesus CSF1 ORF mammalian expression plasmid, N-Myc tag||CG90029-NM|
|Rhesus CSF1 ORF mammalian expression plasmid, N-HA tag||CG90029-NY|
|Rhesus CSF1 natural ORF mammalian expression plasmid||CG90029-UT|
|Learn more about expression Vectors|
Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.