|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Canine IL18R1 ORF mammalian expression plasmid, C-Flag tag||DG70081-CF|
|Canine IL18R1 ORF mammalian expression plasmid, C-His tag||DG70081-CH|
|Canine IL18R1 ORF mammalian expression plasmid, C-Myc tag||DG70081-CM|
|Canine IL18R1 ORF mammalian expression plasmid, C-HA tag||DG70081-CY|
|Canine IL18R1 ORF mammalian expression plasmid, N-Flag tag||DG70081-NF|
|Canine IL18R1 ORF mammalian expression plasmid, N-His tag||DG70081-NH|
|Canine IL18R1 ORF mammalian expression plasmid, N-Myc tag||DG70081-NM|
|Canine IL18R1 ORF mammalian expression plasmid, N-HA tag||DG70081-NY|
|Canine IL18R1 natural ORF mammalian expression plasmid||DG70081-UT|
|Learn more about expression Vectors|
Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.