|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Canine IGF1 ORF mammalian expression plasmid, C-GFPSpark tag||DG70037-ACG|
|Canine IGF1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||DG70037-ACR|
|Canine IGF1 ORF mammalian expression plasmid, C-Flag tag||DG70037-CF|
|Canine IGF1 ORF mammalian expression plasmid, C-His tag||DG70037-CH|
|Canine IGF1 ORF mammalian expression plasmid, C-Myc tag||DG70037-CM|
|Canine IGF1 ORF mammalian expression plasmid, C-HA tag||DG70037-CY|
|Canine IGF1 Gene cDNA clone plasmid||DG70037-G|
|Canine IGF1 ORF mammalian expression plasmid, N-Flag tag||DG70037-NF|
|Canine IGF1 ORF mammalian expression plasmid, N-His tag||DG70037-NH|
|Canine IGF1 ORF mammalian expression plasmid, N-Myc tag||DG70037-NM|
|Canine IGF1 ORF mammalian expression plasmid, N-HA tag||DG70037-NY|
|Canine IGF1 natural ORF mammalian expression plasmid||DG70037-UT|
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IGF I, also known as mechano growth factor, somatomedin-C, IGF-I and IGF1, is a secreted protein which belongs to the?insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.