|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A myc tag is a polypeptide protein tag derived from the c-myc gene product that can be added to a protein using recombinant DNA technology. It can be used for affinity chromatography, then used to separate recombinant, overexpressed protein from wild type protein expressed by the host organism. It can also be used in the isolation of protein complexes with multiple subunits.
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
|Human APLP1 ORF mammalian expression plasmid, C-GFPSpark tag||HG13716-ACG|
|Human APLP1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13716-ACR|
|Human APLP1 ORF mammalian expression plasmid, C-Flag tag||HG13716-CF|
|Human APLP1 ORF mammalian expression plasmid, C-His tag||HG13716-CH|
|Human APLP1 ORF mammalian expression plasmid, C-Myc tag||HG13716-CM|
|Human APLP1 ORF mammalian expression plasmid, C-HA tag||HG13716-CY|
|Human APLP1 Gene cDNA clone plasmid||HG13716-G|
|Human APLP1 ORF mammalian expression plasmid, N-Flag tag||HG13716-NF|
|Human APLP1 ORF mammalian expression plasmid, N-His tag||HG13716-NH|
|Human APLP1 ORF mammalian expression plasmid, N-Myc tag||HG13716-NM|
|Human APLP1 ORF mammalian expression plasmid, N-HA tag||HG13716-NY|
|Human APLP1 natural ORF mammalian expression plasmid||HG13716-UT|
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APLP1, also known as amyloid-like protein 1, is a member of the highly conserved amyloid precursor protein gene family. APLP1 is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. APLP1, together with APLP2, are important modulators of glucose. APLP1 may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. APLP1 also is a mammalian homologue of amyloid precursor protein (APP). APP is a type I membrane protein that is genetically linked to Alzheimer's disease.