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Mouse EPO Receptor / EPOR Protein (Fc Tag)

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Mouse EPOR Protein Product Information
Protein Construction:A DNA sequence encoding the mouse EPOR (NP_034279.3) (Met1-Pro249) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Expressed Host:Baculovirus-Insect cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Mouse EPOR Protein QC Testing
Purity:> 85 % as determined by SDS-PAGE
Bio-Activity:1. Measured by its ability to inhibit EPOdependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.05-0.2 μg/mL in the presence of 16 ng/mL Recombinant mouse EPO.
2. Measured by its binding ability in a functional ELISA.
3. Immobilized mouse EPO-His (Cat:51099-M08H) at 10μg/mL (100 μL/well) can bind mouse EPOR-Fc. The EC50 of mouse EPOR-Fc is 0.06-0.13μg/mL.
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Ala 25
Molecule Mass:The recombinant mouse EPOR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 463 amino acids and has a predicted molecular mass of 51.4 kDa. The apparent molecular mass of the protein is approximately 58.6 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation:Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, pH 7.0.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Mouse EPOR Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Mouse EPOR Protein SDS-PAGE
Mouse EPO Receptor / EPOR Protein (Fc Tag) SDS-PAGE
Mouse EPO Receptor / EPOR Protein (Fc Tag) SDS-PAGE
Mouse EPO Receptor / EPOR Protein (Fc Tag) SDS-PAGE
Other EPOR Recombinant Protein Products
EPOR/Erythropoietin Receptor Background

Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR/EPO Receptor) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR protein is a type â…  single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR signaling prevents neuronal death and ischemic injury. Recent studies have shown that EPO and EPOR protein may be involved in carcinogenesis, angiogenesis, and invasion.

Mouse EPOR/Erythropoietin Receptor References
  • Divoky V, et al. (2002) Mouse surviving solely on human erythropoietin receptor (EpoR): model of human EpoR-linked disease. Blood 99(10): 3873-4.
  • Carruthers SG. (2009) A truncated erythropoietin receptor EPOR-T is associated with hypertension susceptibility. Clin Pharmacol Ther. 86(2): 134-6.
  • Baltaziak M, et al. (2009) Relationships of P53 and Bak with EPO and EPOR in human colorectal cancer. Anticancer Res. 29(10):4151-6.
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    Catalog: 50031-M02B-20
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