After search, choose a molecule or a kind of categories listed in the left to narrow down your filter. If you have any problems, please contact us!
Text Size:AAA

Caspase-14 / CASP14 Antibody (PE), Rabbit MAb

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
Human CASP14 Antibody Product Information
Immunogen:Recombinant Human Caspase-14 / CASP14 protein (Catalog#11856-H07E)
Clone ID:006
Ig Type:Rabbit IgG
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.1% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human Caspase-14 / CASP14 (rh Caspase-14 / CASP14; Catalog#11856-H07E; NP_036246.1; Ser 2-Gln 242) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Human CASP14 Antibody Usage Guide
Specificity:Human Caspase-14 / CASP14
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Human CASP14 Antibody FC Application Image
[Click to enlarge image]
Human CASP14 expression in HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and stained with PE Rabbit anti-CASP14 (Clone R006). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Caspase-14 / CASP14 Antibody (PE), Rabbit MAb, Flow cytometric
Other CASP14 Antibody Products
Caspase-14/CASP14 Background

Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Caspase 14 was not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapaptotic members of the bcl-2 family. Caspase 14 has been described to be processed and activated by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may take part in keratinocyte terminal differentiation, which is essential for the skin barrier.

Human Caspase-14/CASP14 References
  • Hu SM, et al. (1998) Caspase-14 is a novel developmentally regulated protease. The journal of biological chemistry. 273: 29648-53.
  • Marc Van De Craen, et al. (1998) Identification of a new caspase homologue: caspase-14. Cell death differ. 5(10): 838-46.
  • Product nameProduct name