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HER2 / ErbB2 / CD340 Antibody (APC), Rabbit MAb

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ERBB2Antibody Product Information
Antigen:Recombinant Human ErbB2 protein (Catalog#10004-H08H)
Clone ID:511
Ig Type:Rabbit IgG
Concentration:5 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human ErbB2 / HER2 extracellular domain (rh ErbB2; Catalog#10004-H08H; NP_004439.2; Met 1-Thr 652) and conjugated with APC under optimum conditions, the unreacted APC was removed .
ERBB2Antibody Usage Guide
Specificity:Human ErbB2 / HER2 / CD340
No cross-reactivity in ELISA with
Rat ErbB2
Application:FCM
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Images
HER2 / ErbB2 / CD340 Antibody (APC), Rabbit MAb, Flow cytometric
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Caption:
Profile of anti-ErbB2 reactivity on MCF-7 cells analyzed by flow cytometry.

Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Reference
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
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    Size / Price
    Catalog:10004-R511-A-50
    List Price: $130.00  (Save $0.00)
    Price:$130.00      [How to order]
    Availsability:In Stock
    Images
    • HER2 / ErbB2 / CD340 Antibody (APC), Rabbit MAb, Flow cytometric
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