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CD112 / Nectin-2 / PVRL2 Antibody (PE), Mouse MAb

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PVRL2Antibody Product Information
Immunogen:Recombinant Human CD112 protein (Catalog#10005-H08H)
Clone ID:11
Ig Type:Mouse IgG1
Concentration:2 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD112 / Nectin-2 / PVRL2 (rh CD112 / Nectin-2 / PVRL2; Catalog#10005-H08H; Met 1-Leu 360; NP_002847.1) and conjugated with PE under optimum conditions, the unreacted PE was removed.
PVRL2Antibody Usage Guide
Specificity:Human CD112 / Nectin-2 / PVRL2
Application:FCM
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Images
CD112 / Nectin-2 / PVRL2 Antibody (PE), Mouse MAb, Flow cytometric
[Click to enlarge image]
Caption:
Flow cytometric analysis of anti-Human PVRL2 (CD112) on A549 cells.
Background

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

References
  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
  • Related Products
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    Catalog:10005-MM11-P-50
    List Price: $130.00  (Save $0.00)
    Price:$130.00      [How to order]
    AvailabilityIn Stock
    Images
    • CD112 / Nectin-2 / PVRL2 Antibody (PE), Mouse MAb, Flow cytometric
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