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RELA / Transcription factor p65 / NFkB p65 Antibody (FITC), Mouse MAb

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RELAAntibody Product Information
Immunogen:Recombinant Human RELA / Transcription factor p65 / NFkB p65 protein (Catalog#12054-H09E)
Clone ID:04
Ig Type:Mouse IgG2a
Concentration:5 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RELA / Transcription factor p65 / NFkB p65 (rh RELA / Transcription factor p65 / NFkB p65; Catalog#12054-H09E; Q04206-1; Met1-Tyr306) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
RELAAntibody Usage Guide
Specificity:Human RELA / Transcription factor p65 / NFkB p65
No cross-reactivity in ELISA with
Human Coagulation Factor Xa
Human CDKN2D
Human PRDM2
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
RELA / Transcription factor p65 / NFkB p65 Antibody (FITC), Mouse MAb, Flow cytometric
[Click to enlarge image]
Flow cytometric analysis of anti-Human RelA/NFkB p65 onHeLa cells.

RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-?B complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an effective immune response but is also involved in the regulation of cell proliferation, development, and apoptosis. The implication of NF-kappaB in central biological processes and its extraordinary connectivity to other signaling pathways raise a need for highly controlled regulation of NF-kappaB activity at several levels. The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid organs to the control of immune responses and malignant transformation.

  • Hashimoto R, et al. (2011) Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology. 36(9): 1921-31.
  • Vallabhapurapu S, et al. (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 27: 693-733.
  • Schmitz ML, et al. (2004) NF-kappaB: a multifaceted transcription factor regulated at several levels. Chembiochem. 5(10): 1348-58.
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