|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Human IL1R1 ORF mammalian expression plasmid, C-GFPSpark tag||HG10126-ACG|
|Human IL1R1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10126-ACR|
|Human IL1R1 ORF mammalian expression plasmid, C-Flag tag||HG10126-CF|
|Human IL1R1 ORF mammalian expression plasmid, C-His tag||HG10126-CH|
|Human IL1R1 ORF mammalian expression plasmid, C-Myc tag||HG10126-CM|
|Human IL1R1 ORF mammalian expression plasmid, C-HA tag||HG10126-CY|
|Human IL1R1 Gene cDNA clone plasmid||HG10126-M|
|Human IL1R1 ORF mammalian expression plasmid, N-Flag tag||HG10126-NF|
|Human IL1R1 ORF mammalian expression plasmid, N-His tag||HG10126-NH|
|Human IL1R1 ORF mammalian expression plasmid, N-Myc tag||HG10126-NM|
|Human IL1R1 ORF mammalian expression plasmid, N-HA tag||HG10126-NY|
|Human IL1R1 natural ORF mammalian expression plasmid||HG10126-UT|
|Learn more about expression Vectors|
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.