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Granzyme H / GZMH Antibody (PE), Mouse MAb

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Human GZMH Antibody Product Information
Immunogen:Recombinant Human Granzyme H / GZMH protein (Catalog#10348-H08H)
Clone ID:03
Ig Type:Mouse IgG1
Concentration:5 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Granzyme H / GZMH (rh Granzyme H / GZMH; Catalog#10348-H08H; NP_219491.1; Met1-Leu246) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Human GZMH Antibody Usage Guide
Specificity:Human Granzyme H / GZMH
Has cross-reactivity in ELISA with
Human GranzymeB
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Human GZMH Antibody FC Application Image
[Click to enlarge image]
Profile of anti-Human Granzyme H reactivity on A549 cells analyzed by flow cytometry.
Granzyme H / GZMH Antibody (PE), Mouse MAb, Flow cytometric
Other GZMH Antibody Products
Granzyme H/GZMH Background

Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular pathogens. Several granzymes are potent inducers of cell death. A total of eight granzymes (A-G and M) have been identified in the mouse, but only five are known in humans (A, B, H, M and granzyme 3), and granzyme H appears to be specifically human. Human granzyme H is a neutral serine protease that is expressed predominantly in the lymphokine-activated killer (LAK)/natural?killer (NK) compartment of the immune system. In adenovirus-infected cells in which granzyme B (gzmB) and downstream apoptosis pathways are inhibited, granzyme H directly cleaves the adenovirus DNA-binding protein (DBP), a viral component absolutely required for viral DNA replication. This virus demonstrated that gzmH directly induces an important decay in viral DNA replication. Interestingly, gzmH also cleaves the adenovirus 100K assembly protein, a major inhibitor of gzmB, and relieves gzmB inhibition. Granzyme H has a very high amino acid identity (>90%) with many portions of the granzyme B sequence, particularly near the amino terminus of the molecule despite performing a distinct enzymic function.

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