|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Ferret IL1RN ORF mammalian expression plasmid, C-GFPSpark tag||FG60143-ACG|
|Ferret IL1RN ORF mammalian expression plasmid, C-OFPSpark / RFP tag||FG60143-ACR|
|Ferret IL1RN ORF mammalian expression plasmid, C-Flag tag||FG60143-CF|
|Ferret IL1RN ORF mammalian expression plasmid, C-His tag||FG60143-CH|
|Ferret IL1RN ORF mammalian expression plasmid, C-Myc tag||FG60143-CM|
|Ferret IL1RN ORF mammalian expression plasmid, C-HA tag||FG60143-CY|
|Ferret IL1RN Gene cDNA clone plasmid||FG60143-G|
|Ferret IL1RN ORF mammalian expression plasmid, N-Flag tag||FG60143-NF|
|Ferret IL1RN ORF mammalian expression plasmid, N-His tag||FG60143-NH|
|Ferret IL1RN ORF mammalian expression plasmid, N-Myc tag||FG60143-NM|
|Ferret IL1RN ORF mammalian expression plasmid, N-HA tag||FG60143-NY|
|Ferret IL1RN natural ORF mammalian expression plasmid||FG60143-UT|
|Learn more about expression Vectors|
Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein encoding gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth.