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HPGD / 15-PGDH Antibody (FITC), Rabbit MAb

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HPGDAntibody Product Information
Immunogen:Recombinant Human HPGD / 15-PGDH protein (Catalog#11205-H08E)
Clone ID:027
Ig Type:Rabbit IgG
Concentration:5 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human HPGD / 15-PGDH (rh HPGD / 15-PGDH; Catalog#11205-H08E; NP_000851.2; Met1-Gln266) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
HPGDAntibody Usage Guide
Specificity:Human HPGD / 15-PGDH
Application:FCM
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Images
HPGD / 15-PGDH Antibody (FITC), Rabbit MAb, Flow cytometric
[Click to enlarge image]
Caption:
Human HPGD expression in Jurkat cells.
Background

Mouse 15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR) , cranioosteoarthropathy (COA), and isolated congenital nail clubbing.

References
  • Patel, FA. et al., 2003, J. Clin. Endocrinol. Metab. 88: 2922-33.
  • McKeown KJ, et al.,2003, J. Clin. Endocrinol. Metab. 88 (4): 1737-41.
  • Yan, M. et al., 2004, Proc. Natl. Acad. Sci. USA. 101: 17468-73.
  • Tariq, M. et al., 2009, J Med Genet. 46 (1): 14-20.
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    Catalog:11205-R027-F-50
    List Price: $130.00  (Save $0.00)
    Price:$130.00      [How to order]
    AvailabilityIn Stock
    Images
    • HPGD / 15-PGDH Antibody (FITC), Rabbit MAb, Flow cytometric
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