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TROP2 / TACSTD2 Antibody (FITC), Rabbit MAb

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Human TACSTD2 Antibody Product Information
Immunogen:Recombinant Human TROP2 / TACSTD2 protein (Catalog#10428-H08H)
Clone ID:001
Ig Type:Rabbit IgG
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human TROP2 / TACSTD2 (rh TROP2 / TACSTD2; Catalog#10428-H08H; NP_002344.2; Met1-Thr274) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Human TACSTD2 Antibody Usage Guide
Specificity:Human TROP2 / TACSTD2
Application:ICC/IF, FCM, IF

ICC/IF: 10-25 μg/mL

Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Human TACSTD2 Antibody IF Application Image
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Immunofluorescence staining of Human TROP2 in MCF7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Rabbit anti-Human TROP2 monoclonal antibody (FITC-conjugated, 10 µg/ml) at 37℃ 1 hour. Positive staining was localized to plasma membrane.
TROP2 / TACSTD2 Antibody (FITC), Rabbit MAb, Immunofluorescence
Human TACSTD2 Antibody FC Application Image
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Flow cytometric analysis of anti-Human TROP2 on MCF-7 cells.
TROP2 / TACSTD2 Antibody (FITC), Rabbit MAb, Flow cytometric
Other TACSTD2 Antibody Products
TROP-2/TACSTD2 Background

TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.

Human TROP-2/TACSTD2 References
  • Ripani E, et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 76(5): 671-6.
  • Wang J, et al. (2008) Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7(2): 280-5.
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