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LDL Receptor / LDLR Antibody (PE), Rabbit MAb

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LDLRAntibody Product Information
Immunogen:Recombinant Human LDL Receptor / LDLR protein (Catalog#10231-H08H)
Clone ID:301
Ig Type:Rabbit IgG
Concentration:5 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human LDL Receptor / LDLR (rh LDL Receptor / LDLR; Catalog#10231-H08H; NP_000518.1; Met 1-Arg 788) and conjugated with PE under optimum conditions, the unreacted PE was removed.
LDLRAntibody Usage Guide
Specificity:Human LDL Receptor / LDLR
No cross-reactivity in ELISA with
Mouse LDLR
Application:FCM
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Images
LDL Receptor / LDLR Antibody (PE), Rabbit MAb, Flow cytometric
[Click to enlarge image]
Caption:
Profile of anti-Human LDLR reactivity on HepG2 cells analyzed by flow cytometry.
Background

LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.

References
  • Yamamoto T, et al. (1984) The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 39(1): 27-38.
  • Mao B, et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 411(6835): 321-5.
  • Pinson KI, et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407(6803): 535-8.
  • Related Products
    Product nameProduct name
    Size / Price
    Catalog:10231-R301-P-100
    List Price: $200.00  (Save $0.00)
    Price:$200.00      [How to order]
    AvailabilityIn Stock
    Images
    • LDL Receptor / LDLR Antibody (PE), Rabbit MAb, Flow cytometric
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