|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A myc tag is a polypeptide protein tag derived from the c-myc gene product that can be added to a protein using recombinant DNA technology. It can be used for affinity chromatography, then used to separate recombinant, overexpressed protein from wild type protein expressed by the host organism. It can also be used in the isolation of protein complexes with multiple subunits.
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
|Human CSH1 ORF mammalian expression plasmid, C-GFPSpark tag||HG11596-ACG|
|Human CSH1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11596-ACR|
|Human CSH1 ORF mammalian expression plasmid, C-Flag tag||HG11596-CF|
|Human CSH1 ORF mammalian expression plasmid, C-His tag||HG11596-CH|
|Human CSH1 ORF mammalian expression plasmid, C-Myc tag||HG11596-CM|
|Human CSH1 ORF mammalian expression plasmid, C-HA tag||HG11596-CY|
|Human CSH1 Gene cDNA clone plasmid||HG11596-M|
|Human CSH1 ORF mammalian expression plasmid, N-Flag tag||HG11596-NF|
|Human CSH1 ORF mammalian expression plasmid, N-His tag||HG11596-NH|
|Human CSH1 ORF mammalian expression plasmid, N-Myc tag||HG11596-NM|
|Human CSH1 ORF mammalian expression plasmid, N-HA tag||HG11596-NY|
|Human CSH1 natural ORF mammalian expression plasmid||HG11596-UT|
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Chorionic somatomammotropin hormone, also known as Choriomammotropin, Lactogen, Placental lactogen and CSH1, is a secreted protein which belongs to the somatotropin / prolactin family. CSH1 is produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. The CSH1 gene is member of the GH gene cluster on 17q, which consists of two growth hormone genes and three CSH genes. Genomic alterations in the GH cluster are well known, causing different phenotypes depending on the size of the deletion and the genes involved. The increased prevalence of hemizygosity of CSH1 in population in comparison to controls indicates a role for CSH1 haploinsufficiency in the etiology of growth retardation. Investigation of CSH1 deletions in further SRS and growth retarded patients will enable us to establish under which circumstances haploinsufficiency of CSH1 is likely to result in clinical changes.