|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
|Human TNFRSF4 ORF mammalian expression plasmid, C-GFPSpark tag||HG10481-ACG|
|Human TNFRSF4 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10481-ACR|
|Human TNFRSF4 ORF mammalian expression plasmid, C-Flag tag||HG10481-CF|
|Human TNFRSF4 ORF mammalian expression plasmid, C-His tag||HG10481-CH|
|Human TNFRSF4 ORF mammalian expression plasmid, C-Myc tag||HG10481-CM|
|Human TNFRSF4 ORF mammalian expression plasmid, C-HA tag||HG10481-CY|
|Human TNFRSF4 Gene cDNA clone plasmid||HG10481-G|
|Human TNFRSF4 natural ORF mammalian expression plasmid||HG10481-G-N|
|Human TNFRSF4 ORF mammalian expression plasmid, N-Flag tag||HG10481-NF|
|Human TNFRSF4 ORF mammalian expression plasmid, N-His tag||HG10481-NH|
|Human TNFRSF4 ORF mammalian expression plasmid, N-Myc tag||HG10481-NM|
|Human TNFRSF4 ORF mammalian expression plasmid, N-HA tag||HG10481-NY|
|Human TNFRSF4 natural ORF mammalian expression plasmid||HG10481-UT|
|Learn more about expression Vectors|
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.