|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Rhesus IFNG ORF mammalian expression plasmid, C-GFPSpark tag||CG90008-ACG|
|Rhesus IFNG ORF mammalian expression plasmid, C-OFPSpark / RFP tag||CG90008-ACR|
|Rhesus IFNG ORF mammalian expression plasmid, C-Flag tag||CG90008-CF|
|Rhesus IFNG ORF mammalian expression plasmid, C-His tag||CG90008-CH|
|Rhesus IFNG ORF mammalian expression plasmid, C-Myc tag||CG90008-CM|
|Rhesus IFNG ORF mammalian expression plasmid, C-HA tag||CG90008-CY|
|Rhesus IFNG Gene cDNA clone plasmid||CG90008-M|
|Rhesus IFNG ORF mammalian expression plasmid, N-Flag tag||CG90008-NF|
|Rhesus IFNG ORF mammalian expression plasmid, N-His tag||CG90008-NH|
|Rhesus IFNG ORF mammalian expression plasmid, N-Myc tag||CG90008-NM|
|Rhesus IFNG ORF mammalian expression plasmid, N-HA tag||CG90008-NY|
|Rhesus IFNG natural ORF mammalian expression plasmid||CG90008-UT|
|Learn more about expression Vectors|
IFN gamma, also known as IFNG, is a secreted protein which belongs to the type I I interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.