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ASGPR1 / ASGR1 Antibody, Rabbit PAb, Antigen Affinity Purified

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ASGR1Antibody Product Information
Immunogen:Recombinant Human ASGPR1 / ASGR1 protein (Catalog#10773-H07H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human ASGPR1 / ASGR1 (rh ASGPR1 / ASGR1; Catalog#10773-H07H; P07306; Gln62-Leu291). ASGPR1 / ASGR1 specific IgG was purified by Human ASGPR1 / ASGR1 affinity chromatography.
ASGR1Antibody Usage Guide
Specificity:Human ASGPR1 / ASGR1
Application:WB, IHC-P, IP

WB: 0.2-2 μg/mL

IHC-P: 0.1-2 μg/mL

IP: 1-4 μg/mg of lysate

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Images
ASGPR1 / ASGR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human ASGR1 in human cirrhosis with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
ASGPR1 / ASGR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human ASGR1 in human hepatoma with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Background

The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.

References
  • Yang J, et al. (2006) Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. J Viral Hepat. 13(3): 158-65.
  • Li Y, et al. (2008) Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. Curr Drug Deliv. 5(4): 299-302.
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    Images
    • ASGPR1 / ASGR1 Antibody, Rabbit PAb, Antigen Affinity Purified
    • ASGPR1 / ASGR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
    • ASGPR1 / ASGR1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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