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LIMP-2 / SCARB2 / CD36L2 Antibody, Rabbit MAb

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Mouse SCARB2 Antibody Product Information
Immunogen:Recombinant Mouse LIMP-2 / SCARB2 / CD36L2 protein (Catalog#50052-M08H)
Clone ID:052
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse LIMP-2 / SCARB2 / CD36L2 (rM LIMP-2 / SCARB2 / CD36L2; Catalog#50052-M08H; NP_031670.1; Met1-Thr432).
Mouse SCARB2 Antibody Usage Guide
Specificity:Mouse LIMP-2 / SCARB2 / CD36L2
Application:IHC-P

IHC-P: 0.5-5 μg/mL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Mouse SCARB2 Antibody IHC Application Image
[Click to enlarge image]
Caption:
Immunochemical staining of mouse SCARB2 in mouse brain with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
LIMP-2 / SCARB2 / CD36L2 Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse SCARB2 in mouse kidney with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
LIMP-2 / SCARB2 / CD36L2 Antibody, Rabbit MAb, Immunohistochemistry
Other SCARB2 Antibody Products
LIMP-2/SCARB2 Background

Lysosomal Integral Membrane Protein II (LIMPII), also known as SCARB2, LPG85, and CD36L2, is a type I II multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. This protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. LIMPII is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Expression of human LIMPII enables normally unsusceptible cell lines to support the viruses’ propagation and develop cytopathic effects. In addition, LIMPII also has been shown to bind thrombospondin-1, may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation. Deficiency of the protein in mice impairs cell membrane transport processes and causes pelvic junction obstruction, deafness, and peripheral neuropathy.

Mouse LIMP-2/SCARB2 References
  • Crombie, R. et al., 1998, J. Biol. Chem. 273: 4855-4863.
  • Febbraio, M. et al., 2001, J. Clin. Invest. 108: 785-791.
  • Kuronita, T. et al., 2002, J. Cell Sci. 115: 4117-4131.
  • Gamp, A.C. et al., 2003, Human Molecular Genetics. 12: 631-646.
  • Eskelinen, E.L. et al., 2003, Trends in Cell Biology. 13: 137-145.
  • Mulcahy, J.V. et al.,2004, Biochem. J. 377 (Pt 3): 741–747.
  • Yamayoshi, S. et al., 2009, Nat Med. 15 (7): 798-801.
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