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Mouse IL10RB / IL10R2 Protein (His Tag)

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Mouse IL10RB Protein Product Information
Synonym:6620401D04Rik, AI528744, CRF2-4, Crfb4, D16H21S58, D21S58h, IL-10R2, Il10r2
Protein Construction:A DNA sequence encoding the extracellular domain of mouse IL10RB (NP_032375.2) (Met 1-Ser 222) was expressed, with a C-terminal polyhistidine tag.
Expressed Host:Human Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Mouse IL10RB Protein QC Testing
Purity:> 98 % as determined by SDS-PAGE
Bio-Activity:Immobilized mouse IL10RB-His at 10 μg/ml (100 μl/well) can bind biotinylated human IL28B-His (Cat:11890-H08H), The EC50 of biotinylated human IL28B-His (Cat:11890-H08H) is 0.13-0.31 μg/ml.
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Met 22
Molecule Mass:The secreted recombinant mouse IL10RB comprises 212 amino acids and has a calculated molecular mass of 25 kDa. As a result of glycosylation, the apparent molecular mass of rmIL10RB is approximately 35-45 kDa in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Mouse IL10RB Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Mouse IL10RB Protein SDS-PAGE
Mouse IL10RB / IL10R2 Protein (His Tag) SDS-PAGE
Other IL10RB Recombinant Protein Products
IL10RB / IL-10RB Background

Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

Mouse IL10RB / IL-10RB References
  • Josephson K, et al. (2001) Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 15 (1): 35-46.
  • Yoo KH, et al. (2011) Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population. J Korean Med Sci. 26(5): 659-64.
  • Size / Price
    Catalog: 50846-M08H-100
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