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CD8a Antibody (PE), Rabbit MAb

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Mouse CD8A Antibody Product Information
Immunogen:Recombinant Mouse CD8a protein (Catalog#50389-M08H)
Clone ID:208
Ig Type:Rabbit IgG
Concentration:5 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD8a (rM CD8a; Catalog#50389-M08H; NP_001074579.1; Met 1-Tyr 196) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Mouse CD8A Antibody Usage Guide
Specificity:Mouse CD8a
No cross-reactivity in ELISA with
Human CD8A
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Mouse CD8A Antibody FC Application Image
[Click to enlarge image]
Flow cytometric analysis of CD8α expression on spleen lymphocytes. BALB/c splenocytes were stained with PE-conjugated anti-Mouse CD8α (50389-R208-P). The histogram were derived from the gated events based on light scattering characteristics of lymphocytes.
CD8a Antibody (PE), Rabbit MAb, Flow cytometric
Other CD8A Antibody Products
CD8a / Lyt2 Background

Human T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I  membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

Mouse CD8a / Lyt2 References
References Devine, L. et al., 2000, J Immunol. 164 (2): 833-8. Arcaro, A. et al., 2000, J Immunol. 165 (4): 2068-76. Saha, K. et al., 2001, Nat Med. 7 (1): 65-72. Romero, P. et al., 2005, Eur J Immunol. 35 (11): 3092-4.
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