After search, choose a molecule or a kind of categories listed in the left to narrow down your filter. If you have any problems, please contact us!

Quick Order

Text Size:AAA

CD112 / Nectin-2 / PVRL2 Antibody, Rabbit MAb

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
Mouse PVRL2/CD112 Antibody Product Information
Immunogen:Recombinant Mouse PVRL2 protein (Catalog#50318-M08H)
Clone ID:110
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PVRL2 extracellular domain (rM PVRL2; Catalog#50318-M08H; NP_033016.3; Met 1-Gly 351).
Mouse PVRL2/CD112 Antibody Usage Guide
Specificity:Mouse PVRL2 / CD112 / Nectin-2
No cross-reactivity in ELISA with
Human CD112 / Nectin-2
Application:WB, ELISA, IP

WB: 20-50 μg/ml

ELISA: 0.5-1 μg/mL

This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Mouse PVRL2. The detection limit for Mouse PVRL2 is 0.00245 ng/well.

IP: 1-4 μg/mg of lysate

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Mouse PVRL2/CD112 Antibody WB Application Image
CD112 / Nectin-2 / PVRL2 Antibody, Rabbit MAb, Western blot
Mouse PVRL2/CD112 Antibody IP Application Image
CD112 / Nectin-2 / PVRL2 Antibody, Rabbit MAb, Immunoprecipitation
Other PVRL2/CD112 Antibody Products
CD112/Nectin-2/PVRL2 Background

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

Mouse CD112/Nectin-2/PVRL2 References
  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
  • Product nameProduct name