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REN1 / Renin-1 Antibody, Rabbit MAb

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Mouse RENIN Antibody Product Information
Immunogen:Recombinant Mouse REN1 protein (Catalog#50279-M08H)
Clone ID:1
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse REN1 (rM REN1; Catalog#50279-M08H; NP_112469.1; Met 1-Arg 402).
Mouse RENIN Antibody Usage Guide
Specificity:Mouse REN1 / Renin-1
No cross-reactivity with in ELISA
Mouse Cathepsin D / CTSD
Application:ELISA, IHC-P

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse REN1. The detection limit for Mouse REN1 is approximately 0.0049 ng/well.

IHC-P: 2-15 μg/mL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Mouse RENIN Antibody IHC Application Image
[Click to enlarge image]
Immunochemical staining of mouse REN1 in mouse kidney with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to juxtaglomerular cell. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
REN1 / Renin-1 Antibody, Rabbit MAb, Immunohistochemistry
Other RENIN Antibody Products
Renin Background

Mouse Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. Renin-1 is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. It is expressed at relatively low levels in mouse SMG and kidney. Ren-2 is expressed at high levels in the mouse SMG and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression.

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