After search, choose a molecule or a kind of categories listed in the left to narrow down your filter. If you have any problems, please contact us!

Quick Order

Text Size:AAA

Human MAPK8 transcript variant JNK1-b2 natural ORF mammalian expression plasmid

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
Human MAPK8 cDNA Clone Product Information
NCBI RefSeq:NM_001278547.1
RefSeq ORF Size:1284bp
cDNA Description:Full length Clone DNA of Homo sapiens mitogen-activated protein kinase 8, transcript variant JNK1-b2.
Gene Synonym:JNK, JNK1, PRKM8, SAPK1, JNK1A2, JNK21B1/2
Species:Human
Vector:pCMV3-untagged
Plasmid:
Restriction Site:
Tag Sequence:
Sequence Description:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Storage:The lyophilized plasmid can be stored at room temperature for three months.
Human MAPK8 transcript variant JNK1-b2 natural ORF mammalian expression plasmid on other vectors
Human MAPK8 transcript variant JNK1-b2 ORF mammalian expression plasmid, C-GFPSpark tagHG10795-ACG$325
Human MAPK8 transcript variant JNK1-b2 ORF mammalian expression plasmid, C-OFPSpark / RFP tagHG10795-ACR$325
Human MAPK8 transcript variant JNK1-b2 ORF mammalian expression plasmid, N-GFPSpark tagHG10795-ANG$325
Human MAPK8 transcript variant JNK1-b2 ORF mammalian expression plasmid, N-OFPSpark / RFP tagHG10795-ANR$325
Human MAPK8 transcript variant JNK1-b2 ORF mammalian expression plasmid, C-Flag tagHG10795-CF$295
Human MAPK8 transcript variant JNK1-b2 ORF mammalian expression plasmid, C-His tagHG10795-CH$295
Human MAPK8 transcript variant JNK1-b2 ORF mammalian expression plasmid, C-Myc tagHG10795-CM$295
Human MAPK8 transcript variant JNK1-b2 ORF mammalian expression plasmid, C-HA tagHG10795-CY$295
Human MAPK8 transcript variant JNK1-b2 Gene cDNA clone plasmidHG10795-M$95
Human MAPK8 transcript variant JNK1-b2 ORF mammalian expression plasmid, Flag tagHG10795-M-F$295
Human MAPK8 transcript variant JNK1-b2 natural ORF mammalian expression plasmidHG10795-M-N$295
Human MAPK8 transcript variant JNK1-b2 ORF mammalian expression plasmid, N-Flag tagHG10795-NF$295
Human MAPK8 transcript variant JNK1-b2 ORF mammalian expression plasmid, N-His tagHG10795-NH$295
Human MAPK8 transcript variant JNK1-b2 ORF mammalian expression plasmid, N-Myc tagHG10795-NM$295
Human MAPK8 transcript variant JNK1-b2 ORF mammalian expression plasmid, N-HA tagHG10795-NY$295
Human MAPK8 transcript variant JNK1-b2 natural ORF mammalian expression plasmidHG10795-UT$295
 Learn more about expression Vectors
Product nameProduct name
Background

Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The protein kinases JNK1 has been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. It is critically involved in the promotion of diet-induced obesity, metabolic inflammation and beta-cell dysfunction. The selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. Genetic analysis indicates that the effects of JNK1 can be separated from effects of JNK1 on obesity. JNK1 is a potential pharmacological target for the development of drugs that might be useful for the treatment of metabolic syndrome, and type 2 diabetes. Furthermore, JNK1 plays a major role in the hypoxic cellular damage. JNK1 protein might be an attractive target for antihypoxic therapy in increasing resistance to many pathological conditions and diseases, leading to the oxygen deficit.

References
  • Betigeri S, et al. (2006) JNK1 as a molecular target to limit cellular mortality under hypoxia. Mol Pharm. 3(4): 424-30.
  • Solinas G, et al. (2010) JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J. 24(8): 2596-611.
  • Sabio G, et al. (2010) Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev. 24(3): 256-64.
  • Size / Price
    Catalog: HG10795-UT
    List Price:   (Save )
    Price:      [How to order]
    Availability2-3 weeksShipping instructions
    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"