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Human ICAM-2 / CD102 transcript variant 5 natural ORF mammalian expression plasmid

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Human ICAM2 cDNA Clone Product Information
Gene_bank_ref_id:NM_000873.3
RefSeq ORF Size:828bp
cDNA Description:ORF Clone of Homo sapiens intercellular adhesion molecule 2 (ICAM2), transcript variant 5 DNA.
Gene Synonym:CD102
Species:Human
Vector:pCMV3-untagged
Plasmid:
Restriction Site:KpnI + ApaI
Tag Sequence:
Sequence Description:Identical with the Gene Bank Ref. ID sequence except for four point mutations: 1-4 ATGC/GTCC resulting in the amino acid variation.
Sequencing primers:
Promoter:
Application:
Antibiotic in E.coli:
Antibiotic in mammalian cell:
Shipping_carrier:
Storage:The lyophilized plasmid can be stored at room temperature for three months.
Human ICAM2 Gene Plasmid Map
Human ICAM-2 / CD102 transcript variant 5 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged
Product nameProduct name
Background

Intercellular adhesion molecule 2 (ICAM-2, CD102), belongs to the ICAM family consisting of three members identified as ligands for integrin receptors. It is a type I transmembrane glycoprotein with two Ig-like C2-type domains, and binds to the leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). As a second ligand of leukocyte function-associated antigen-1, ICAM-2 functions as a costimulatory molecule for effector cells. ICAM-2 is mainly expressed on vascular endothelial and hematopoietic cells. Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocytewith other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. Serum levels of ICAM-2 correlated significantly with the inflammatory and course sequences of trichinosis in mice and had a similar relation with blood eosinophilia. So, estimation of ICAM-2 serum levels may prove useful in diagnosis of trichinosis recent infections, and in monitoring the prognosis and response to treatment.

References
  • Weber KS, et al. (2004) Sialylation of ICAM-2 on platelets impairs adhesion of leukocytes via LFA-1 and DC-SIGN. Inflammation. 28(4): 177-88.
  • Tanaka H, et al. (2004) ICAM-2 gene therapy for peritoneal dissemination of scirrhous gastric carcinoma. Clin Cancer Res. 10(14): 4885-92.
  • Younis AI, et al. (2005) Intercellular adhesion molecule-2 (ICAM-2) in experimental trichinosis. J Egypt Soc Parasitol. 35(3): 1019-26.
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    Catalog: HG10332-UT
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