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Human LRP1 qPCR primer pairs

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Human LRP1 qPCR Product Information
Gene Synonym:APR, LRP, A2MR, CD91, APOER, TGFBR5, IGFBP3R, FLJ16451, MGC88725, LRP1
PCR_SIZE (bp):
QPCR Primer Description:Verified forward and reverse primers for analyzing the quantitative expression of gene
Quality Control:The primer mix has been verified to generate satisfactory qPCR data on Roche LightCycler480
Shipping_carrier:1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions) is shipped at ambiente temperatura.
Storage:The lyophilized product is stable for one year from date of receipt when stored at -20℃.
The suspended product is stable for six months from date of receipt when stored at -20℃.
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Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.

Unique Primer Design

To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.

Strict Validation Process

Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.

Uniform PCR conditions, Saving time and cost

~100% amplification curve, ensuring the accuracy of the RNA quantitative

LRP1 (CD91) Background

Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is an endocytic receptor involved in several cellular processes. LRP1 / CD91 is a member of the cluster of differentiation (CD) system. The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. LRP1 / CD91 is involved in endocytosis and in phagocytosis of apoptotic cells and is required for early embryonic development. LRP1 / CD91 is also Involved in cellular lipid homeostasis, the plasma clearance of chylomicron remnants, activated LRPAP1 (alpha 2-macroglobulin), and the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. LRP1 / CD91 May modulate cellular events, such as APP metabolism kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission need the involvement of LRP1 / CD91.

Human LRP1 (CD91) References
  • Su HP, et al. (2002) Interaction of CED-6 / GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91 / low density lipoprotein receptor-related protein (LRP). J Biol Chem. 277(14): 11772-9.
  • Chen JS, et al. (2010) Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91 / LRP-1 and NF-kappaB-mediated integrin alphaV expression. J Biol Chem. 285(33): 25458-66.
  • Dasgupta S, et al. (2008) Factor VIII bypasses CD91 / LRP for endocytosis by dendritic cells leading to T-cell activation. Haematologica. 93(1): 83-9.
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    Catalog: HP101509
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