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FOLR2 Antibody, Rabbit MAb

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
Human FOLR2 Antibody Product Information
Immunogen:Recombinant Human FOLR2 protein (Catalog#11219-H08H)
Clone ID:001
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human FOLR2 (rh FOLR2; Catalog#11219-H08H; P14207-1; Met1-His228).
Human FOLR2 Antibody Usage Guide
Specificity:Human FOLR2
Application:WB, IHC-P

WB: 30-50 μg/ml

IHC-P: 1-10 μg/mL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human FOLR2 Antibody WB Application Image
FOLR2 Antibody, Rabbit MAb, Western blot
Human FOLR2 Antibody IHC Application Image
[Click to enlarge image]
Caption:
Immunochemical staining of human FOLR2 in human placenta with rabbit monoclonal antibody (1 µg/mL,formalin-fixed paraffin embedded sections).
FOLR2 Antibody, Rabbit MAb, Immunochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human FOLR2 in human spleen with rabbit monoclonal antibody (1 µg/mL,formalin-fixed paraffin embedded sections).
FOLR2 Antibody, Rabbit MAb, Immunochemistry
Other FOLR2 Antibody Products
FOLR2 Background

Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potocytosis. FOLR2 has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.

Human FOLR2 References
  • van Heyningen V, et al., 1995, Cytogenet Cell Genet. 69 (3-4): 127-58.
  • Sabharanjak, S. et al., 2004, Adv Drug Deliv Rev. 56 (8): 1099-109. 
  • Scapoli, L. et al., 2005, Am J Med Genet A. 132A (3): 302-4.
  • Puig-Kröger, A. et al., 2009, Cancer Res  69 (24): 9395-403.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"