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CD19 Antibody, Rabbit MAb

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CD19Antibody Product Information
Immunogen:Recombinant Human CD19 protein (Catalog#11880-H08H)
Clone ID:109
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human CD19 (rh CD19; Catalog#11880-H08H; P15391; Met1-Lys291).
CD19Antibody Usage Guide
Specificity:Human CD19
Application:IHC-P

Immunochemical staining of human CD19 in human tonsil with rabbit monoclonal antibody (3 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of B cells.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Images
CD19 Antibody, Rabbit MAb, Immunochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human CD19 in human tonsil with rabbit monoclonal antibody (3 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of B cells.
CD19 Antibody, Rabbit MAb, Immunochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human CD19 in human spleen (from 2 donors) with rabbit monoclonal antibody (3 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of B cells.
Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 19 (CD19) is a member of CD system. CD19 is a cell surface molecule that assembles with the antigen receptor of B-cells. This results in a descent in threshold for antigen receptor-dependent stimulation. A simplified view holds that the ability of B-cells to respond to the various antigens in a specific and sensitive manner is achieved in the presence of low-affinity antigen receptors. CD19 primarily acts as a B-cell coreceptor in conjunction with CD21 and CD81. The formation of the receptor complex is induced by antigen and CD19, induced by exogenous antigen, has been found cytoplasmic tail phosphorylated and bind to sIg.

References
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Carter RH, et al. (1992) CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science. 256 (5053): 105-7.
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    Catalog:11880-R109-100
    List Price: $290.00  (Save $0.00)
    Price:$290.00      [How to order]
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    • CD19 Antibody, Rabbit MAb, Immunochemistry
    • CD19 Antibody, Rabbit MAb, Immunochemistry
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