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Clusterin / Apolipoprotein J / Apo-J / CLU Antibody, Rabbit MAb

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Human CLU Antibody Product Information
Immunogen:Recombinant Human Clusterin / Apolipoprotein J / Apo-J / CLU protein (Catalog#11297-H08H)
Clone ID:210
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human Clusterin / Apolipoprotein J / Apo-J / CLU (rh Clusterin / Apolipoprotein J / Apo-J / CLU; Catalog#11297-H08H; NP_001822.2; Met1-Glu501).
Human CLU Antibody Usage Guide
Specificity:Human Clusterin / Apolipoprotein J / Apo-J / CLU
Has cross-reactivity in ELISA with
Mouse CLU
Application:IHC-P

IHC-P: 1-10 μg/mL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human CLU Antibody IHC Application Image
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Caption:
Immunochemical staining of human CLU in human appendix with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Clusterin / Apolipoprotein J / Apo-J / CLU Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human CLU in human ovarian cancer with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Clusterin / Apolipoprotein J / Apo-J / CLU Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human CLU in human pancreas with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Clusterin / Apolipoprotein J / Apo-J / CLU Antibody, Rabbit MAb, Immunohistochemistry
Other CLU Antibody Products
Clusterin/Apolipoprotein J/Apo-J Background

Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease. Its major form, a heterodimer, is secreted and present in physiological fluids, but truncated forms targeted to the nucleus have also been identified. Clusterin/Apolipoprotein J/Apo-J is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Human Clusterin/Apolipoprotein J/Apo-J References
  • Silkensen JR, et al. (1994) The role of clusterin in tissue injury. Biochem Cell Biol. 72(11-12): 483-8.
  • Naik RR, et al. (2002) Biomimetic synthesis and patterning of silver nanoparticles. Nat Mater. 1(3): 169-72.
  • Djeu JY, et al. (2009) Clusterin and chemoresistance. Adv Cancer Res. 105: 77-92.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"