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ALK-1 / ACVRL1 Antibody, Rabbit MAb

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Human ACVRL1 Antibody Product Information
Immunogen:Recombinant Human ALK-1 / ACVRL1 protein (Catalog#10066-H08H)
Clone ID:124
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human ALK-1 / ACVRL1 (rh ALK-1 / ACVRL1; Catalog#10066-H08H; NP_000011.2; Met1-Gln118).
Human ACVRL1 Antibody Usage Guide
Specificity:Human ALK-1 / ACVRL1
Application:WB, IP

WB: 2-10 μg/mL

IP: 1-4 uL/mg of lysate

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human ACVRL1 Antibody WB Application Image
ALK-1 / ACVRL1 Antibody, Rabbit MAb, Western blot
Human ACVRL1 Antibody IP Application Image
ALK-1 / ACVRL1 Antibody, Rabbit MAb
Other ACVRL1 Antibody Products
ALK-1 / ACVRL1  Background

Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.

Human ALK-1 / ACVRL1  References
  • French Rendu-Osler network,et al. (2004) Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France. Hum Mutat. 23(4): 289-299.
  • Simon M, et al. (2006) Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system. J Neurosurg. 104(6): 945-9.
  • Argyriou L, et al. (2006) Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia. Int J Mol Med. 17(4):655-9.
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