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AK4 / Adenylate Kinase 4 / AK3L1 Antibody (PE), Mouse MAb

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Human AK4 Antibody Product Information
Immunogen:Recombinant Human AK4 / Adenylate Kinase 4 / AK3L1 protein (Catalog#12406-H20B)
Clone ID:09
Ig Type:Mouse IgG1
Concentration:5 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human AK4 / Adenylate Kinase 4 / AK3L1 (rh AK4 / Adenylate Kinase 4 / AK3L1; Catalog#12406-H20B; P27144-1; Ala2-Tyr223) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Human AK4 Antibody Usage Guide
Specificity:Human AK4 / Adenylate Kinase 4 / AK3L1
No cross-reactivity in ELISA with
Human CACM5
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Human AK4 Antibody FC Application Image
[Click to enlarge image]
Flow cytometric analysis of Human AK4 expression on HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with PE Mouse anti-Human AK4. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
AK4 / Adenylate Kinase 4 / AK3L1 Antibody (PE), Mouse MAb, Flow cytometric analysis
Other AK4 Antibody Products
AK4 / Adenylate Kinase 4 / AK3L1 Background

Adenylate kinase isoenzyme 4, mitochondrial, also known as ATP-AMP transphosphorylase, Adenylate kinase 3-like, AK4 and AK3L1, is a member the adenylate kinase family. AK4 / AK3L1 is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. AK4 / AK3L1 catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. It may also be active with GTP. Adenylate kinase 4 ( AK4 / AK3L1 ) is a unique member with no enzymatic activity in the adenylate kinase (AK) family although it shares high sequence homology with other AKs. It remains unclear what physiological function AK4 might play or why it is enzymatically inactive. AK4 / AK3L1 retains the capability of binding nucleotides. It has a glutamine residue instead of a key arginine residue in the active site well conserved in other AKs. The enzymatically inactive AK4 is a stress responsive protein critical to cell survival and proliferation. AK4 / AK3L1 is likely that the interaction with the mitochondrial inner membrane protein ANT is important for AK4 to exert the protective benefits to cells under stress. AK4 / AK3L1 also acts on the specific mechanism of energy metabolism rather than control of the homeostasis of the ADP pool ubiquitously.

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