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MCP-3 / CCL7 Antibody (PE), Mouse MAb

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Human CCL7 Antibody Product Information
Immunogen:Recombinant Human MCP-3 / CCL7 protein (Catalog#11926-H08E)
Clone ID:18
Ig Type:Mouse IgG1
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MCP-3 / CCL7 (rh MCP-3 / CCL7; Catalog#11926-H08E; NP_006264.2; Gln24-Leu99) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Human CCL7 Antibody Usage Guide
Specificity:Human MCP-3 / CCL7
Has cross-reactivity in ELISA with
Human CCL1
Human CCL8
No cross-reactivity in ELISA with
Human CCL11
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Human CCL7 Antibody FC Application Image
[Click to enlarge image]
Flow cytometric analysis of Human CCL7 expression on THP1 cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with PE-conjugated anti-Human CCL7. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
MCP-3 / CCL7 Antibody (PE), Mouse MAb, Flow Cytometry
Other CCL7 Antibody Products
MCP-3/CCL7 Background

Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 7(CCL7), also known as MCP-3, is a isform of the C-C chemokine subfamily of the chemokine family which is produced by certain tumor cells and by macrophages. It also own two adjacent N-terminal cysteine residues. Chemokine ligand 7(CCL7) spacifically attracts monocytes, and regulates macrophage function.

Human MCP-3/CCL7 References
  • Laing KJ, et al. (2004) Chemokines. Developmental and comparative immunology. 28(5): 443-60.
  • Cocchi F, et al. (1995) Identification of RANTES, MIP-1a, and MIP-1b as the major HIV-suppressive factor produced by CD8+ T cells. Science. 270 (5243): 1811-5.
  • Michalec L, et al. (2002) CCL7 and CXCL10 Orchestrate Oxidative Stress-Induced Neutrophilic Lung Inflammation. The Journal of Immunology. 168: 846-52.
  • Wetzel K,et al. (2007) MCP-3 (CCL7) delivered by parvovirus MVMp reduces tumorigenicity of mouse melanoma cells through activation of T lymphocytes and NK cells.International Journal of Cancer. 120(6):1364-71.
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