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SIGNR1 / CD209b Antibody (PE), Rabbit MAb

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CD209BAntibody Product Information
Immunogen:Recombinant Mouse SIGNR1 / CD209b protein (Catalog#50486-M07H)
Clone ID:143
Ig Type:Rabbit IgG
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SIGNR1 / CD209b (rM SIGNR1 / CD209b; Catalog#50486-M07H; NP_081248.2; Gln74-Gly325) and conjugated with PE under optimum conditions, the unreacted PE was removed.
CD209BAntibody Usage Guide
Specificity:Mouse SIGNR1 / CD209b
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
SIGNR1 / CD209b Antibody (PE), Rabbit MAb, Flow cytometric analysis
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Flow cytometric analysis of Mouse CD209b expression on mouse splenocytes. BABL/c splenocytes were stained with PE-conjugated anti-Mouse CD209b and PerCP-Cy™5.5 conjugated anti-Mouse CD19 (BD Pharmingen™). The dot plots were derived from gated events with the forward and side light-scatter characteristics of intact cells.

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD209b, also known as SIGNR1, is a C-type lectin receptor. CD209b is present on most regions of mouse brain and found on microglia and dendritic cells but not on neurons or astrocytes. CD209b is implicated in the recently described SIGNR1 complement activation pathway, which operates against capsular polysaccharides in splenic marginal macrophages. CD209b in rat is homologue to SIGNR1 in mouse, both of which are found to mediate the uptake of dextran or CPS14 within the splenic marginal zone.

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