Quick Order

Text Size:AAA

KIR2DL1 / CD158a Antibody (APC), Rabbit MAb

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
KIR2DL1Antibody Product Information
Immunogen:Recombinant Human KIR2DL1 / CD158a protein (Catalog#13145-H08H)
Clone ID:124
Ig Type:Rabbit IgG
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human KIR2DL1 / CD158a (rh KIR2DL1 / CD158a; Catalog#13145-H08H; NP_055033.2; Met1-His245) and conjugated with APC under optimum conditions, the unreacted APC was removed.
KIR2DL1Antibody Usage Guide
Specificity:Human KIR2DL1 / CD158a
Application:FCM
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Images
KIR2DL1 / CD158a Antibody (APC), Rabbit MAb, Flow cytometric analysis
[Click to enlarge image]
Caption:
Flow cytometric analysis of human KIR2DL1(CD158a) expression on human whole blood lymphocytes. Human whole blood lymphocytes were stained with APC-conjugated anti-Human KIR2DL1(CD158a). The histogram were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
Background

Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain. KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and in KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and in a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal.

References
  • Fan QR, et al. (2001) Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nature Immunology. 2: 452-60.
  • Wagtmann N, et al. (1995) Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity. 2 (5): 439-49.
  • Colonna M, et al. (1995) Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science. 268 (5209): 405-8.
  • Related Products
    Product nameProduct name
    Size / Price
    Catalog:13145-R124-A-100
    List Price: $200.00  (Save $0.00)
    Price:$200.00      [How to order]
    Availabilityon Sale
    Images
    • KIR2DL1 / CD158a Antibody (APC), Rabbit MAb, Flow cytometric analysis
    Recently Viewed Items
      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"