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CD8a / Lyt2 Antibody (APC), Rabbit MAb

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CD8AAntibody Product Information
Immunogen:Recombinant Ferret CD8a / Lyt2 protein (Catalog#60001-F08H)
Clone ID:073
Ig Type:Rabbit IgG
Concentration:5 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Ferret CD8a / Lyt2 (rF CD8a / Lyt2; Catalog#60001-F08H; ABS50091.1; Met1-Glu186) and conjugated with APC under optimum conditions, the unreacted APC was removed.
CD8AAntibody Usage Guide
Specificity:Ferret CD8a / Lyt2
Application:FCM
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Images
CD8a / Lyt2 Antibody (APC), Rabbit MAb, Flow cytometric analysis
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Caption:
Analysis of Ferret CD8A expression on ferret splenocytes. Ferret splenocytes were stained with APC-conjugated rabbit anti-Ferret CD8A. The histogram were derived from the gated events based on light scattering characteristics of viable cells.
Background

Human T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I  membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

References
References Devine, L. et al., 2000, J Immunol. 164 (2): 833-8. Arcaro, A. et al., 2000, J Immunol. 165 (4): 2068-76. Saha, K. et al., 2001, Nat Med. 7 (1): 65-72. Romero, P. et al., 2005, Eur J Immunol. 35 (11): 3092-4.
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Catalog:60001-R073-A-100
List Price: $200.00  (Save $0.00)
Price:$200.00      [How to order]
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  • CD8a / Lyt2 Antibody (APC), Rabbit MAb, Flow cytometric analysis
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