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ICOS Ligand / B7-H2 Antibody (PE), Mouse MAb

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ICOSLGAntibody Product Information
Immunogen:Recombinant Human ICOS Ligand / B7-H2 protein (Catalog#11559-H08H)
Clone ID:01
Ig Type:Mouse IgG1
Concentration:5 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ICOS Ligand / B7-H2 (rh ICOS Ligand / B7-H2; Catalog#11559-H08H; NP_056074.1; Met1-Ser258) and conjugated with PE under optimum conditions, the unreacted PE was removed.
ICOSLGAntibody Usage Guide
Specificity:Human ICOS Ligand / B7-H2
Application:FCM
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Images
ICOS Ligand / B7-H2 Antibody (PE), Mouse MAb, Flow cytometric analysis
[Click to enlarge image]
Caption:
Flow cytometric analysis of ICOSLG(CD275) expression on RPMI8226 cells.
Background

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

References
  • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
  • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
  • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.
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    Catalog:11559-MM01-P-100
    List Price: $200.00  (Save $0.00)
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    • ICOS Ligand / B7-H2 Antibody (PE), Mouse MAb, Flow cytometric analysis
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