After search, choose a molecule or a kind of categories listed in the left to narrow down your filter. If you have any problems, please contact us!
Text Size:AAA

Syndecan-4 / SDC4 Antibody (PE), Rabbit MAb

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
Mouse SDC4 Antibody Product Information
Immunogen:Recombinant Mouse Syndecan-4 / SDC4 protein (Catalog#50726-M08H)
Clone ID:112
Ig Type:Rabbit IgG
Concentration:2 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Syndecan-4 / SDC4 (rM Syndecan-4 / SDC4; Catalog#50726-M08H; O35988; Met1-Val146) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Mouse SDC4 Antibody Usage Guide
Specificity:Mouse Syndecan-4 / SDC4
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Mouse SDC4 Antibody FC Application Image
[Click to enlarge image]
Flow cytometric analysis of mouse SDC4 expression on mouse splenocytes. BABL/c splenocytes were stained with PE-conjugated anti-Mouse SDC4 and FITC-conjugated anti-Mouse CD3 (BD Pharmingen™ Cat. No.553061, left) or APC-conjugated anti-Mouse CD19 (BD Pharmingen™ Cat. No.550992, right).
Syndecan-4 / SDC4 Antibody (PE), Rabbit MAb, Flow cytometric analysis
Other SDC4 Antibody Products
Syndecan-4/SDC4 Background

SDC4 (Syndecan-4), also known as Syn4, is a transmembrane heparan sulfate proteoglycan that co-operates with integrins during cell-matrix interactions for the assembly of focal adhesions and actin stress fibers and in the phosphorylation of focal adhesion kinase (FAK) on Tyr397. Syndecan-4 plays roles in the formation of focal adhesions and stress fibers. The cytoplasmic domain of syndecan-4 interacts with a number of signalling and structural proteins, and both extracellular and cytoplasmic domains are necessary for regulated activation of associated transmembrane receptors. Syndecan-4/SDC4 is a heparan sulfate proteoglycan and works as a coreceptor for various growth factors. SDC4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cells (VSMCs) proliferation and vascular progenitor cells (VPCs) mobilization. Therefore, SDC4 may be a novel therapeutic target for preventing arterial restenosis after angioplasty.

Mouse Syndecan-4/SDC4 References
  • Ikesue M, et al. (2011) Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. Arterioscler Thromb Vasc Biol. 31(5): 1066-74.
  • Saoncella S, et al. (2004) Syndecan-4 regulates ATF-2 transcriptional activity in a Rac1-dependent manner. J Biol Chem. 279(45): 47172-6.
  • Bass MD, et al. (2002) Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. Biochem J. 368(Pt 1): 1-15.
  • Couchman JR, et al. (1999) Syndecan-4 and integrins: combinatorial signaling in cell adhesion. J Cell Sci. 112 ( Pt 20): 3415-20.
  • Product nameProduct name