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IL37 / IL1F7 / IL-1H4 Antibody, Rabbit PAb, Antigen Affinity Purified

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Human IL37 Antibody Product Information
Immunogen:Recombinant Human IL37 / IL1F7 / IL-1H4 protein (Catalog#10155-HNAE)
Clone ID:
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS
Preparation:Produced in rabbits immunized with purified, recombinant Human IL37 / IL1F7 / IL-1H4 (rh IL37 / IL1F7 / IL-1H4; Catalog#10155-HNAE; Q9NZH6-2; Lys27-Asp192). IL37 / IL1F7 / IL-1H4 specific IgG was purified by Human IL37 / IL1F7 / IL-1H4 affinity chromatography.
Human IL37 Antibody Usage Guide
Specificity:Human IL37 / IL1F7 / IL-1H4

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IL37 / IL1F7 / IL-1H4. The detection limit for Human IL37 / IL1F7 / IL-1H4 is < 0.039 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other IL37 Antibody Products
IL37 / IL1F7 / IL-1H4 Background

Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7 may be involved in immune response, inflammatory diseases and / or cancer. Through constructing an adenoviral vector that allows high level expression in murine and human cells, it has been demonstrated that the ability of adenovirus-mediated gene transfer of IL1F7 to induce an IL-12- and Fas ligand-dependent anti-tumor response. Complete inhibition of tumor growth was observed following multiple injections of IL1F7 in the most animals. These results suggest that IL1F7 could play a role in both innate and adaptive immune responses, similar to IL-18. Moreover, IL1F7 could be useful for cancer gene therapy. 

Human IL37 / IL1F7 / IL-1H4 References
  • Gao W, et al. (2003) Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. J Immunol. 170 (1): 107-13.
  • Bufler P, et al. (2002) A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. Proc Natl Acad Sci. 99 (21): 13723-8.
  • Kumar S, et al. (2002) Interleukin-1F7B (IL-1H4 / IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. Cytokine. 18 (2): 61-71.
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