|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Recombinant Human CLEC1B / CLEC2 protein (Catalog#10976-H07H)|
|0.2 μm filtered solution in PBS|
|Produced in rabbits immunized with purified, recombinant Human CLEC1B / CLEC2 (rh CLEC1B / CLEC2; Catalog#10976-H07H; NP_057593.3; Gln58-Pro229). CLEC1B / CLEC2 specific IgG was purified by Human CLEC1B / CLEC2 affinity chromatography.|
|Human CLEC1B / CLEC2|
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CLEC1B / CLEC2. The detection limit for Human CLEC1B / CLEC2 is < 0.039 ng/well.
|This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.|
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. CLEC2 contains 1 C-type lectin domain and is expressed preferentially in the liver. It acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.