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Frizzled-1 / FZD1 Antibody, Rabbit PAb, Antigen Affinity Purified

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FZD1Antibody Product Information
Immunogen:Recombinant Mouse Frizzled-1 / FZD1 protein (Catalog#50092-M08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS
Preparation:Produced in rabbits immunized with purified, recombinant Mouse Frizzled-1 / FZD1 (rh Frizzled-1 / FZD1; Catalog#50092-M08H; NP_067432.2; Met1-His248). Frizzled-1 / FZD1 specific IgG was purified by Mouse Frizzled-1 / FZD1 affinity chromatography.
FZD1Antibody Usage Guide
Specificity:Mouse Frizzled-1 / FZD1
Application:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse Frizzled-1 / FZD1. The detection limit for Mouse Frizzled-1 / FZD1 is < 0.039 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Background

Frizzled-1, also known as FZD1, belongs to the G-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. FZD1 is expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol. Frizzled proteins and the genes encoding them have been identified in an array of animals, from sponges to humans. Frizzled proteins play key roles in governing cell polarity, embryonic development, formation of neural synapses, cell proliferation, and many other processes in developing and adult organisms. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.

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Catalog:50092-T16-100
List Price: $290.00  (Save $0.00)
Price:$290.00      [How to order]
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