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Tie2 / CD202b / TEK Antibody (APC), Mouse MAb

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TEKAntibody Product Information
Immunogen:Recombinant Human Tie2 / CD202b / TEK protein (Catalog#10700-H08H)
Clone ID:07
Ig Type:Mouse IgG1
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Tie2 / CD202b / TEK (rh Tie2 / CD202b / TEK; Catalog#10700-H08H; NP_000450.2; Met1-Lys745) and conjugated with APC under optimum conditions, the unreacted APC was removed.
TEKAntibody Usage Guide
Specificity:Human Tie2 / CD202b / TEK
No cross-reactivity in ELISA with
Human Tie1
Human Ang2
Application:FCM
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Images
GSTM2 Antibody, Rabbit MAb, Immunohistochemistry
[Click to enlarge image]
Caption:
Tie2 / CD202b / TEK Antibody (APC), Mouse MAb, Flow cytometric analysis
Background

TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.

References
  • Jones N, et al. (1998) The Tek / Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene. 17(9): 1097-108.
  • Sato A, et al. (1998) Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int Immunol. 10(8): 1217-27.
  • Huang L, et al. (1995) GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK / TIE2 receptor tyrosine kinase. Oncogene. 11(10): 2097-103.
  • Angiopoietin/Tie Related Products
    Size / Price
    Catalog:10700-MM07-A-100
    List Price: $200.00  (Save $0.00)
    Price:$200.00      [How to order]
    Availabilityon Sale
    Images
    • GSTM2 Antibody, Rabbit MAb, Immunohistochemistry
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