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LDL Receptor / LDLR Antibody (APC), Rabbit MAb

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Human LDLR Antibody Product Information
Immunogen:Recombinant Human LDL Receptor / LDLR protein (Catalog#10231-H08H)
Clone ID:301
Ig Type:Rabbit IgG
Concentration:5 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human LDL Receptor / LDLR (rh LDL Receptor / LDLR; Catalog#10231-H08H; NP_000518.1; Met 1-Arg 788) and conjugated with APC under optimum conditions, the unreacted APC was removed.
Human LDLR Antibody Usage Guide
Specificity:Human LDL Receptor / LDLR
No cross-reactivity in ELISA with
Mouse LDLR
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Human LDLR Antibody FC Application Image
[Click to enlarge image]
LDL Receptor / LDLR Antibody (APC), Rabbit MAb, Flow cytometric analysis
FCGRT & B2M Antibody, Rabbit MAb, Immunohistochemistry
Other LDLR Antibody Products
LDL Receptor Background

LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.

Human LDL Receptor References
  • Yamamoto T, et al. (1984) The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 39(1): 27-38.
  • Mao B, et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 411(6835): 321-5.
  • Pinson KI, et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407(6803): 535-8.
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