|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rhesus EPCAM ORF mammalian expression plasmid, C-GFPSpark tag||CG90299-ACG|
|Rhesus EPCAM ORF mammalian expression plasmid, C-OFPSpark / RFP tag||CG90299-ACR|
|Rhesus EPCAM ORF mammalian expression plasmid, C-Flag tag||CG90299-CF|
|Rhesus EPCAM ORF mammalian expression plasmid, C-His tag||CG90299-CH|
|Rhesus EPCAM ORF mammalian expression plasmid, C-Myc tag||CG90299-CM|
|Rhesus EPCAM ORF mammalian expression plasmid, C-HA tag||CG90299-CY|
|Rhesus EPCAM Gene cDNA clone plasmid||CG90299-G|
|Rhesus EPCAM ORF mammalian expression plasmid, N-Flag tag||CG90299-NF|
|Rhesus EPCAM ORF mammalian expression plasmid, N-His tag||CG90299-NH|
|Rhesus EPCAM ORF mammalian expression plasmid, N-Myc tag||CG90299-NM|
|Rhesus EPCAM ORF mammalian expression plasmid, N-HA tag||CG90299-NY|
|Rhesus EPCAM natural ORF mammalian expression plasmid||CG90299-UT|
|Learn more about expression Vectors|
Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.